Review on Sublingual Drug Delivery System

Abstract

Drug delivery via the oral mucous membrane is considered to be a promising alternative to the oral route. Sublingual route is a useful when rapid onset of action is desired with better patient compliance than orally administered drugs. In terms of permeability, the sublingual area of the oral cavity is more permeable than the buccal area, which in turn is more permeable than the roof of the mouth area. The portion of drug absorbed through the sublingual blood vessels avoids hepatic first‐pass metabolic processes giving good bioavailability. Sublingual technology for patients need enhanced lifecycle management to convenient dosing forgeriatric, pediatric and patient with dysphagia. This review highlights the introduction of sublingual drug delivery,mechanism ,factors affecting sublingual absorption, advantages, disadvantages,methods of preparation(tablet,films),drug administered by this route and conclusion. Keywords: Improved bioavailability, Sublingual delivery, Dysphagia, Technique.