Abstract
Intraperitoneal administration of Lanthanum strontium manganese oxide (LaSMnO3) a new class of magnetic nanoparticle on mouse testosterone and fertility was investigated. For this, experimental mice divided into 4 groups (n=5); group I, II, III and IV were treated with vehicle (control), 5, 10 and 20 µg/kg/day of LaSMnO3 for 21 days respectively. Five animals from each group were sacrificed at interval of 0, 7, 14 and 21 days, however, after twenty-one days of the treatment, animals in all groups were allowed to cohabited with untreated female mice for fertility study. Toxic effects of LaSMnO3 on the testosterone and sperm parameters were analyzed. Effect on ROS and anti-oxidative biomarkers were also measured. Significant decrease (p<0.05) of epididymal spermatozoa motility and numbers was measured revealing the cytotoxicity effects of this nanomaterial. Light microscopic study revealed changes in the cauda epididymal sperm morphology. Failure of the fertility in LaSMnO3-treated mice as evidenced by the significant reduction in the average number of implantation in females mated with the treated males. Depletion of testicular testosterone hormone level by high dose of LaSMnO3 (20µg/kg/day) shows a reduced testicular androgen synthesis. This study therefore, shows the potential adverse effect of LaSMnO3 on male fertility.
Keywords: Lanthanum strontium manganese oxide nanoparticle, animal models, toxicity, fertility
Publisher
Society of Pharmaceutical Tecnocrats