Author:
AKHTAR FARHAN,Azhar Misbahuddin,Aslam Mohd,Javed Kalim
Abstract
Background: The nephroprotective effect of crude powder of Asgand (Withania samnifera Dunal) was studied against cisplatin induced renal toxicity in wistar albino rats of either sex.
Results: The powder of Withania somnifera Dunal at dose level 700 and 1400 mg/kg body wt/day showed reduction in elevated blood urea, serum creatinine and uric acid. It was found to protect kidney damage by cisplatin induced nephrotoxicity as evidenced by oral administration of Asgand (Withania samnifera Dunal) (700 mg/kg) inhibited the rise in blood urea nitrogen (121.7%), Serum cratinine (76.64%), and uric acid (92.7%). There were 92.71% inhibition in the rise of BUN, 92% inhibition in the rise of serum creatinine and 106.6% inhibition in the rise of uric acid with 1400 mg.
Conclusion: The findings suggest that the famous Unani herb Asgand Powder possesses marked nephroprotective activity and could offer a promising role in the treatment of acute renal injury caused by nephrotoxins like cisplatin.
Keywords: Withania somnifera Dunal, Cisplatin, Asgand, Nephroprotection, Unani Medicine
Publisher
Society of Pharmaceutical Tecnocrats
Reference34 articles.
1. 1. Rozeneweig M, Van Hoff DD, Slavil M, Muggia FM, Cis-diamine dichloroplatinum, a new anticancer agent, Annals of Internal Medicine, 1977;86(6):803-809.
2. 2. Livingston RB. Cisplatin in the treatment of solid tumors: effect of dose and schedule. J. National Cancer Institute, 1989; 81(10):724-725.
3. 3. Kuhlmann MK, Burkhardt G, Kohler H, Insights into potential cellular mechanisms of cisplatin nephrotoxicity and their clinical application, Nephrol Dial. Tranplant, 1997; 12(12):2478-2480.
4. 4. Garnick MB, Mayer RJ, Abelson HT. Acute renal failure associated with cancer treatment. In: Acute renal failure. Eds. B.M. Brenner & J.M. Lazarus. Churchill Livingstone, New York; 1988. P. 621-657.
5. 5. Madias NE, Harrington JT, Platinum nephotoxicty, American Journal of Medicine, 1978; 65(1):307-314.
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献