Histological study of the effects of aluminum chloride exposure on the brain of wistar rats female

Abstract

Introduction: Aluminum (Al) has the potential to be neurotoxic in human and animals, is present everywhere in the environment, many manufactured foods and medicines and is also added to drinking water for purification purposes and tooth paste cosmetic products They accumulate in living organisms and disrupt balances, and accumulate in the body biological systems, causing toxic effects (They may affect the nervous system, kidney, liver, respiratory or other functions). Nervous system is a vulnerable target for toxicants due to critical voltages which must be maintained in the cells and the all responses when voltages reach threshold levels. Objective This study aimed to expose the impact of aluminum chloride (AlCl3) on brain architecture. Methods: In our study, twenty healthy female rats were intraperitoneal administered of aluminum chloride (ALCL3) at 10 mg / kg body weight with consecutively for 15 day Result. The results showed a highly significant reduction in body weight (p<0.0001).  This is because aluminum has an anorectic effect contrariwise, there is no significant impact of aluminium exposure has been observed with respect to brain weight and relative brain weight respectively (p<0.912), (p<0.45). The histological study describes the alterations in the brain marked tissue necrosis and cytoplasmic vacuolations and karyopyknosis of neuronal cells of the brain. Conclusion; Aluminum is a toxic heavy metal and a ubiquitous environmental pollutant. It can alter the permeability of the blood-brain barrier and enter the brain, severely affecting the functioning of the nervous system. Keywords: Toxicity, brain, Aluminium chloride, Rats female, necrosis.