Solid self‑emulsifying pellets: Solubility enhancement for oral delivery of poorly soluble BCS Class II drug

Abstract

The review focused on technique of solid self-emulsifying pellets (SEPs) for solubility enhancement of poorly water soluble drug. The oral route of administration has been and still is currently the primary route of drug delivery owing to its potential advantages compared to the other routes. The solubility enhancement process of hydrophobic drugs plays a key role in the formulation development to achieve the bioavailability and therapeutic action of the drug at the target site.1 Around 40% of probe new drugs are characterized as belonging to class II in the BCS classification (poorly water soluble and highly permeable), giving rise to poor and erratic oral bioavailability. The solid SEPs system combines the advantages of liquid Self emulsifying drug delivery system with those of solid dosage form, which can overcome the limitations of liquid formulations and improve the storage stability and patient compliance. To enhance the dissolution and oral absorption of water insoluble drug selfmicroemulsifying pellets develop and evaluated. SEPs pellets showed a significant quicker redispersion rate than the dissolution rate of commercial tablets. The solid SEPs pellets might be an encouraging strategy to improve the oral absorption of Poorly water soluble drug and the extrusion–spheronization method is a feasible technology for the solidification of liquid SMEPs. Self microemulsifying drug delivery system (SEPs) as an effective bioavailability enhancement pharmaceutical technology has been widely used during the recent years and have some successful products in the market (e.g. Neoral®, Norvir® and Fortovase®). Keywords: Self Emulsifying Pellets, Bioavailability, Solubility, extrusion–spheronization, Biopharmaceutical Classification.