Abstract
The [DBN][HSO4] -promoted Knoevenagel condensation followed by cyclization protocol has been developed for the first time by a successive reaction of aldehydes, dimedone and malononitrile to afford 2-Amino-4H-pyrans derivatives in high to excellent yields at room temperature. The synergic couple of microwave and ionic liquid provided the capability to allow a variability of functional groups, short reaction times, easy workup, high yields, recyclability of the catalyst, and solvent-free conditions, thus providing economic and environmental advantages.
Keywords: [DBN][HSO4], Environmentally benign, 2-Amino-4H-pyrans, Knoevenagel condensation, Microwave irradiation
Publisher
Society of Pharmaceutical Tecnocrats
Reference60 articles.
1. 1. Morinaka Y, Takahashi K, Jpn. Patent 1977; JP52017498
2. 2. Witte EC, Neubert P, Roesch A, Ger. Offen. 1986; DE3427985.
3. 3. Hafez EA, Elnagdi MH, Elagamey AG, El-Taweel, FMA, Nitriles in heterocyclic synthesis: novel synthesis of benzo[c]coumarin and of benzo[c]pyrano[3,2-cc]quinoline derivatives, Heterocycles 1987; (26) 903-907
4. 4. Kuthan J, Pyrans, Thiopyrans, and Selenopyrans, Adv. Heterocycl. Chem. 1983; (34): 145-303
5. 5. Hatakeyama S, Ochi N, Numata H, Takano S, A new route to substituted 3-methoxycarbonyldihydropyrans; enantioselective synthesis of (-)-methyl elenolate, J. Chem. Soc. Chem. Commun. 1988; (17): 1202-1204
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