Comparative study of the anticoagulant powers of the aqueous macerate, ethanolic macerate and aqueous decoction of the leaves of Uvaria chamae P. Beauv. (Annonaceae)

Abstract

Data on the anticoagulant power of Uvaria chamae, a plant used in traditional medicine, remain unknown despite its many therapeutic and biological virtues. The present study aimed to compare the anticoagulant effects of aqueous macerate, ethanolic macerate and aqueous decoction of U. chamae leaves. The anticoagulant activity of macerated and decocted U. chamae was evaluated in vitro against endogenous and exogenous coagulation pathways in a pool of displaced normal plasmas. These two pathways are explored using two global and chronometric tests including Cephalin-Kaolin Time (TCK) and Prothrombin Time (TQ). The results obtained revealed that the incubation time of U. chamae macerates and decoctions with plasma significantly influences their anticoagulant power. This evaluation showed that these macerated and decocted products exerted anticoagulant power at concentrations dependent on these two coagulation pathways. This anticoagulant power at the level of the aqueous decocted was more significant (P ˂ 0.001) on these two coagulation pathways but it was more marked on the endogenous pathway than on the exogenous pathway. This anticoagulant power at the level of the aqueous decocted was more significant (P ˂ 0.001) on these two coagulation pathways but it was more marked on the endogenous pathway than on the exogenous pathway. This Ivorian plant could thus be considered as a natural source of anticoagulant agents for medicinal purposes. Keywords: Uvaria chamae, Anticoagulant, Aqueous macerate, Ethanolic macerate, Aqueous decocted