COMPUTATIONAL ASSESSMENT OF UNDARIA PINNATIFIDA AND MORINGA OLEIFERA COMPOUNDS AS ANTI-OBESITY AGENTS

Abstract

Objective: The objective of this topic is to discuss the potential of using bioactive substances of Undaria Pinnatifida Ethanolic Extract of (UPEE) and Moringa Oleifera Methanolic Extract of (MOME) extracts as pharmacological agents and inhibitors of Peroxisome Proliferator-Activated Receptor gamma (PPAR-γ), Fat Mass and Obesity-Associated (FTO), Resistin and leptin to counter obesity. Methods: The study uses Gas Chromatography-Mass Spectrometry (GC-MS) and Fourier-Transform InfraRed (FTIR) Spectroscopy techniques to identify the bioactive components of these extracts and evaluates their efficacy through in silico assessments and molecular docking analysis. Results: Analysis of docking results revealed that ligand interaction with FTO (ID: 3LFM) docking complex showed good binding affinity, binding oreintation, pharmocological properties. Hence, the best ligands were proposed as the best antagonist to block PPAR-γ, FTO, Resistin and leptin, which plays major role in the drug devolopment pathways. Conclusion: UPEE and MOME extracts acts as pharmacological agents for anti-obesity genes. PPAR-γ-4CI5 has a best docking score (-7.716 kcal/mol), as a result. As a result, the standard was recommended as the best antagonist to block the key enzyme involved in the drug development pathways.