INVESTIGATING THE ROLE OF NANOPARTICLE-BASED CURCUMIN IMPLANTS IN PREVENTION OF POST-LAPAROTOMY PERITONEAL ADHESION: AN IN VIVO STUDY

Abstract

Objective: The objective of this research is to develop a controlled-release drug delivery system for relieving peritoneal adhesion. The system is designed to utilize a polymer hydrogel incorporating Curcumin (cur) loaded Mesoporous Silica Nanoparticles (Msn). Its objective is to improve the properties of curcumin and reduce peritoneal adhesion after laparoscopic surgery. Methods: The rats in each group underwent intra-abdominal adhesion modeling surgery and received the following implants: implants containing Msn loaded with cur (imp/Msn@cur), Implants Containing Cur (imp/cur), implants containing Msn without cur (imp/Msn), Implants without Msn and cur (imp) and group only modeled (contrl). After 14 d, the surgical site was reopened and the specimens were evaluated by gross processing and histology staining for adhesion band formation, fibrosis, and inflammation. Data were analyzed by SPSS v.22 using Fisher's exact test, one-way ANOVA, and Tukey's test and P˂0.05 was considered statistically significant. Results: The number of vascularized or non-vascularized adhesion bands was evaluated According to the results, the number of vascular bands in the control group was only significantly higher than the other groups (P<0.001). Also, the mean number of vascular adhesion bands in the imp group was significantly higher than the other intervention groups (P<0.001). All studied rats in the contrl group had adhesions and the severity of adhesions in this group was higher than the others. Also, in the imp/Msn@cur group, the severity of adhesion was the lowest than the other groups. Conclusion: The research findings indicated that utilizing implants with cur-loaded Msn resulted in improved peritoneal adhesion and reduced collagen bandages following laparotomy.