OSMOTIC DRUG DELIVERY SYSTEM OF NICORANDIL: DESIGN AND EVALUATION

Author:

CHOUDHARY SRILATHAORCID,SUBRAHMANYAM CVS,PRIYANKA K.

Abstract

Objective: The purpose of the current research was to design a nicorandil formulation with controlled drug release using the principles of osmotic pump technology. Nicorandil is a biopharmaceutical classification system (BCS) class 3 drug, having a shorter plasma elimination half-life and bioavailability of 75 to 80%. Methods: The elementary osmotic pump (EOP) was prepared by coating a cellulose acetate polymer on the prepared core tablet. A 24-factorial design was applied to optimize the parameters for the osmotic tablet. A surface orifice was drilled. Results: Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and powder X-ray diffraction (PXRD) results showed that there was no interaction between drugs and excipients. A 24-factorial design was applied to optimize the parameters for the elementary osmotic pump. The optimized batch was characterized for in vitro drug release studies, and the effects of pH, osmotic pressure, and agitation intensity were analyzed. All the batches showed a drug release ranging from 90.48% to 98.78% after 12 hours. There was no change in the drug release pattern at different pHs and agitation intensities. The drug release was found to decrease with the increasing osmotic pressure of the dissolution medium. The results showed that the amounts of sodium chloride and mannitol were positively affecting the drug release, while the plasticizers PEG400 and DBP were not critical. Scanning electron microscopic studies (SEM) showed the integrity and surface morphology of the coating membrane before and after dissolution. The prepared EOP was found to deliver nicorandil at zero-order for up to 12 hours. Conclusion: Nicorandil was developed successfully as a controlled drug delivery during a 12-hour period, with variables optimized by the use of a 24-factorial design.

Publisher

Innovare Academic Sciences Pvt Ltd

Reference26 articles.

1. Adepu S, Ramakrishna S. Controlled drug delivery systems: current status and future directions. Molecules. 2021;26(19). doi: 10.3390/molecules26195905, PMID 34641447.

2. Arafat M. Approaches to achieve an oral controlled release drug delivery system using polymers. A recent review. Int J Pharm Pharm Sci. 2015 Jul 1;7(7):16-21.

3. Kunal NP, Tejal AM. A review on oral osmotically driven systems. Int J Pharm Pharm Sci. 2013 May 20;5(3):1005-13.

4. Shireen F, Ajitha M, Roshan S. Development of nateglinide modified release dosage form using elementary osmotic pump and push-pull osmotic pump methods. Int J Pharm Sci Res. 2022 Feb 1;13(2):891-901. doi: 10.13040/IJPSR.0975-8232.

5. Mehta TA, Kunal P. Development and optimization of an elementary osmotic pump tablet of nicardipine hydrochloride using a central composite experimental design. Int J Drug Dev Res. 2013 Jul 9;5(3):382-95.

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