Author:
SANTOSO ASTRID WIDHOWATY,SHAFURIA AMIRA,DEWI TENNY SETIANI
Abstract
Objective: To discuss the management of oral erythema multiforme (EM) due to methotrexate (MTX) in gestational trophoblastic tumor patients.
Methods: A 28-year-old woman was referred to the Oral Medicine Clinic with complaints of pain throughout the oral cavity accompanied by blackish encrustation on the upper and lower lip for 5 d. She previously underwent the first cycle of chemotherapy using MTX for the treatment of a gestational trophoblastic tumor. Extraoral, multiple diffuse blackish patches on the face and haemorrhagic crusts on the lips with painful erosions. Intraoral, multiple erosive and ulcerative lesions on the labial and buccal mucosa.
Results: Management involved topical 0.025% hyaluronic acid mouthwash for erosion and ulceration, compressed 0.9% NaCl for crusted lesions on the lips, and petroleum jelly for the non-crusted lesions on the lips. Complete healing of oral and lip lesions was achieved within 10 d.
Conclusion: Pharmacological management should be tailored to each patient with careful consideration of treatment risk or benefit. In our case, the use of non-steroidal anti-inflammatory topical agents was considered successful in treating oral EM.
Publisher
Innovare Academic Sciences Pvt Ltd
Reference38 articles.
1. Neville BW, Damm DD, Allen CM, Chi AC. Color atlas of oral and maxillofacial diseases. Philadelpia. Elsevier; 2019.
2. Trayes KP, Love G, Studdiford JS. Erythema multiforme: recognition and management. Am Fam Physician. 2019;100(2):82-8. PMID 31305041.
3. Rajendran ABS. Shafer’s textbook of oral pathology. 6th ed. New Delhi: Elsevier India; 2009.
4. Joseph TI, Vargheese G, George D, Sathyan P. Drug-induced oral erythema multiforme: a rare and less recognized variant of erythema multiforme. J Oral Maxillofac Pathol. 2012;16(1):145-8. doi: 10.4103/0973-029X.92995, PMID 22434953.
5. Nazir A, Ali K. Drug-induced erythema multiforme-oral variant: a case report. Oral Maxillofac Surg Cases. 2022;8(1). doi: 10.1016/j.omsc.2021.100241.