ANTI-ACNE CREAM OF LEAVES EXTRACT OF FIG (FICUS CARICA L.) FROM CIWIDEY DISTRICT, INDONESIA, AGAINST PROPIONIBACTERIUM ACNES AND STAPHYLOCOCCUS EPIDERMIDIS

Abstract

Objective: This study aimed to formulate and evaluate an anti-acne cream of fig leaves extract. Methods: The methods included formulation and evaluation of anti-acne cream, antibacterial activity assay against Propionibacterium acnes and Staphylococcus epidermidis, irritancy test, and preference test. The oil-in-water creams were made with various extract concentrations (1, 2, and 3%). Results: Greenish cream with fig fragrant, viscosity ranging from 332 to 388 cP, pH ranging from 6.69 to 7.23, and oil-in-water type. Antibacterial activity was dose-dependent, without irritancy, erythema, and edema, and the most preferred cream based on the texture and fragrance was the 3% extract formula. Conclusion: Fig leaves extract can be made into a safe cream with antibacterial activity against P. acnes and S. epidermidis.