FORMULATION AND IN VITRO EVALUATION OF SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM OF QUERCETIN FOR ENHANCEMENT OF ORAL BIOAVAILABILITY

Abstract

Objective: The study aims to develop a Self-nanoemulsifying drug delivery system (SNEDDS) of Quercetin to enhance its oral bioavailability. Methods: In the present study, Quercetin was formulated into SNEDDS using various oils, surfactants, and co-surfactants. The developed formulations were subjected to various studies like drug content analysis, droplet size and thermodynamic stability, and in vitro drug release studies. Results: From the screening of oils, surfactant and cosurfactant, the combination of Triacetin as oil phase, Tween 20 as surfactant and Ethanol as co-surfactant was selected for the development of SNEDDS of Quercetin. The composition of the formulation was optimized using pseudo ternary phase diagram. The optimized formulation has been evaluated and found to have good physical stability and improved in vitro drug release. Conclusion: A stable SNEDDS of Quercetin was developed, and results indicated substantial enhancement in the dissolution of the drug when formulated as a self-nano emulsifying drug delivery system, indicating its potential to enhance oral solubility and bioavailability of the drug.