ELUCIDATION OF THE BIOCHEMICAL MECHANISMS INVOLVED IN GENETIC BASIS OF LOW INCIDENCE OF DIABETES MELLITUS WITH SPECIFIC REFERENCE TO RAICA COMMUNITY OF RAJASTHAN

Abstract

Objective: The purpose of this study is to evaluate the genotypic variables linked to lower type-2 diabetes prevalence in the raica population in Rajasthan, India. Methods: 150 participants from outside the Raica community and 114 participants from it were recruited for this study for ARNT gene and 112 from Raica and 86 from non-Raica for GLUT4 gene. Their age and sex, body mass index, waist-to-hip ratio, and laboratory results for fasting blood glucose were all taken into account. RFLP was used for genetic study. Results: In this study, 114 participants from Raica community and 150 from non-Raica community were recruited. There were 40 females and 74 males in Raica group and 52 females and 98 males in non-Raica group for ARNT gene. For GLUT4 gene, 112 participants were recruited from Raica and 86 participants from non-Raica community. Raica community showed lower number of participants with fasting glucose>126 mg/dl, BMI>23. Allelic distribution of ARNT and GLUT4 was also lower among Raica. Conclusion: The examined genetic variation is equally prevalent in Raica and non-Raica individuals, diabetes circumstances included.