COMPARATIVE STUDY OF CISATRACURIUM AND ATRACURIUM IN DIFFERENT DOSES FOR INTUBATION DURING GENERAL ANESTHESIA IN LOWER ABDOMINAL SURGERY: A PROSPECTIVE RANDOMIZED DOUBLE-BLIND INTERVENTIONAL TRIAL

Abstract

Objective: General anesthesia requires smooth endotracheal intubation, aided by neuromuscular blocking agents. Atracurium and cis-atracurium are non-depolarizing agents used for muscle relaxation. Succinylcholine, though effective, has undesirable side effects. This study aims to compare atracurium and different doses of cis-atracurium to assess their onset, duration, recovery, hemodynamic effects, and side effects, in order to identify the ideal agent for intubation. Methods: The study will compare atracurium (0.5 mg/kg) with two different doses of cis-atracurium, namely 0.10 mg/kg and 0.15 mg/kg. The parameters evaluated will include the onset of neuromuscular blockade, duration of blockade, recovery time, hemodynamic effects, and incidence of side effects. Neuromuscular monitoring will be employed to ensure proper dosing and prevent residual paralysis. Results: The study will provide valuable data on the comparative characteristics of atracurium and cis-atracurium at different doses. This includes their onset of action, duration of neuromuscular blockade, recovery time, impact on hemodynamic parameters, and occurrence of side effects. The results will shed light on the efficacy, safety, and tolerability of these drugs for endotracheal intubation. Conclusion: The study aims to identify the most suitable neuromuscular blocking agent for facilitating endotracheal intubation by comparing atracurium and different doses of cis-atracurium. By assessing their onset, duration, recovery time, hemodynamic effects, and side effect profiles, clinicians can make informed decisions to optimize patient care during general anesthesia.