SYNTHESIS AND ANTI-MICROBIAL ACTIVITY OF 1-(6-NITRO-2H-BENZO[b][1,4]THIAZINE-3(4H)-YLIDENE)HYDRAZINE-1,1-DIOXIDE DERIVATIVES

Abstract

<p><strong>Objective: </strong>The objective of this research was to synthesize and evaluate anti-microbial properties of 1-(6-nitro-2<em>H</em>-benzo[<em>b</em>][1,4]thiazine-3(4<em>H</em>)-ylidene)hydrazine-1,1-dioxide derivatives.</p><p><strong>Methods: </strong>These new compounds were synthesized by reaction of 2<em>H</em>-benzo[b][1,4]thiazin-3(4<em>H</em>)-one with hydrazine derivatives and oxidized at the sulfur atom by 30% hydrogen peroxide to obtain sulfones. All the synthesized compounds were evaluated for antimicrobial activity using the disc diffusion method.</p><p><strong>Results: </strong>The FTIR, ¹HNMR, ¹³CNMR and Mass studies confirms the synthesis of some new 1-(6-nitro-2<em>H</em>-benzo[<em>b</em>][1,4]thiazine-3(4<em>H</em>)-ylidene) hydrazine-1,1-dioxide derivatives. Compound 5f showed potent antimicrobial activity whereas compounds 5c and 5e showed moderate antimicrobial activity.</p><strong>Conclusion: </strong>Result obtained in this research work clearly indicated that the compound 5f having methyl at 2 position and nitro groups at 2′ and 4′ position showed the most potent antimicrobial activity.<p> </p>