A REVIEW OF NANOGELS AS NOVEL DRUG DELIVERY SYSTEMS

Abstract

The term “nanogel” refers to highly cross-linked hydrogels with a size between 20 and 200 nm. Due to their tiny size, they have higher penetration and greater drug-loading capacity. They release the medication using mechanisms such as photochemical internalization, volume transition, pH responsiveness, thermo sensitive, and photo isomerization. They can be categorized according to whether they respond to stimuli or not as well as the kind of links that are present in the gel structure’s network chains. Using photolithography, modified pollutants, and emulsions, one can create nanogel. Reverse microemulsion polymerization, inverse mini-emulsion polymerization, and the free radical cross-linking polymerization method are all examples of polymerization. Cancer, diabetes, inflammation, and bone regeneration are just a few conditions that can be treated with nanogels. The cutting-edge medication delivery technology for both hydrophilic and hydrophobic drugs is nanogels. This article focuses on the historical data regarding herbal nanogels, which have high patient compliance, delivery rate, and efficacy when used to treat various illnesses. The topic of stimulus-responsive nanogels, including pH-and temperature-responsive systems, is also covered.