A STUDY ON BIOCHEMICAL PARAMETERS IN ASSESSING THE SEVERITY OF ACUTE ORGANOPHOSPHORUS POISONING

Abstract

Objectives: Organophosphorus (OP) poisoning is an important global health issue with increasing mortality rate for every year particularly in developing countries since its overuse in agricultural activity. The present study was performed to analyze the clinical profile and biochemical parameters such as serum cholinesterase, serum creatinine phosphokinase (CPK), liver enzymes, serum amylase, lipase, serum k+, troponin, serum urea, and creatinine on day 1 for correlation with clinical severity of poisoning. Methods: A observational study was performed on 100 cases with OP poisoning at a tertiary care center. Peradeniya OP Poisoning Scale was applied to all cases at the time of admission and the severity was designated as mild, moderate, and severe taking into account 5 vital parameters such as miosis, fasciculations, respiration rate, bradycardia, and level of consciousness and data were statistically analyzed by SPSS. Results: Rise in clinical severity of poisoning and substantial reduction in the level of serum cholinesterase was observed. The mean serum CPK, troponin T (Trop T), amylase, lipase, bilirubin, aspartate aminotransferase, and alanine aminotransferase showed marked elevation according to the severity of OP poisoning. In addition, serum potassium levels showed decreased level as per the severity level. Conclusion: Initial serum cholinesterase and serum Trop T are strong predictors of the clinical severity of OP poisoning.