Author:
KUMARI NEETU,SUTHAR NEHA,KAUR JASWANT,DWIVEDI JYOTI,K VYAS R
Abstract
Objectives: Pre-eclampsia produces potentially lethal complications including placental abruption, hepatic failure, acute renal failure, and cardiovascular collapse. The present study was planned to find the association between serum lactate dehydrogenase (LDH) and gamma-glutamyl transferase (GGT) with pre-eclampsia and compare it with normal healthy control.
Methods: This hospital-based case–control study was conducted in the biochemistry department in collaboration with the Department of Gynaecology, Sardar Patel Medical College, Bikaner (Raj). 50 subjects to find whether there are any changes in the levels of serum LDH and GGT in pre-eclamptic patients (case group) compared to that of 50 normal pregnant women (control group).
Results: The present study has shown statistically significant (p<0.001) increases in serum LDH levels and GGT in pre-eclamptic patients compared to control subjects.
Conclusion: Serum LDH and GGT screening in early pregnancy may be helpful in predicting the occurrence of pre-eclampsia.
Publisher
Innovare Academic Sciences Pvt Ltd
Subject
Pharmacology (medical),Pharmaceutical Science,Pharmacology
Reference16 articles.
1. Cunningham FG, Leveno KJ, Bloom SL, Hauth Dwight JC, Rouse J, Spong CY. Williams Obstetrics. 23rd ed. New York: McGraw- Hill; 2010. p. 706-56.
2. Mushambi MC, Halligan AW, Williamson K. Recent developments in the pathophysiology and management of pre-eclampsia. Br J Anaesth 1996;76:133-48. doi: 10.1093/bja/76.1.133, PMID 8672356
3. Mehta M, Parashar M, Kumar R. Serum lactate dehydrogenase: A prognostic factor in pre-eclampsia. Int J Reprod Contracept Obstet Gynecol 2019;8:2792. doi: 10.18203/2320-1770.ijrcog20193044
4. Yilmaz MI, Turgut F, Kanbay M, Saglam M, Sonmez A, Yaman H,et al. Serum gamma-glutamyltransferase levels are inversely related to endothelial function in chronic kidney disease. Int Urol Nephrol 2013;45:1071-8. doi: 10.1007/s11255-012-0354-2, PMID 23242503
5. Qublan HS, Ammarin V, Bataineh O, Al-Shraideh Z, Tahat Y, Awamleh I, et al. Lactic dehydrogenase as a biochemical marker of adverse pregnancy outcome in severe pre-eclampsia. Med Sci Monit 2005;11:CR393-7.