Author:
SHANKARAPPA DEEPAK,KUMAR P VENKATA NAVEEN,JAFRIN A LOURDU,SUNDARAM G SOMA
Abstract
Objective: Chronic mild stress is the most valid model in inducing depression in rodents. In this method, rats were subjected to CMS for 6 weeks of stress. Methods: In this method, rodents were subjected to a series of mild stressors for CMS for six weeks in an unpredictable manner. Results: Biochemical and pathological changes were observed. Lycopene treatment at 10 mg/kg and 20 mg/kg could revert these biochemical changes. Histopathological studies showed there is a neuronal loss in CMS and CMS+Vehicle groups. Lycopene treatment reverted this condition. Conclusion: Lycopene treatment might revert this biochemical change by inhibiting a rate-limiting enzyme, HMG-CoA reductase. Histopathology of the brain revealed that rats subjected to chronic mild stress showed a decreased neuronal loss in the hippocampus. Lycopene treatment showed a neuroprotective effect against CMS-induced neuronal loss.
Publisher
Innovare Academic Sciences Pvt Ltd
Subject
Pharmacology (medical),Pharmaceutical Science,Pharmacology
Reference17 articles.
1. Sinha SP, Shrivastava SR, Ramasamy J. Depression in an older adult rural population in India. MEDICC Rev 2013;15:41-4.
2. Buvneshkumar M, John KR, Logaraj M. A study on prevalence of depression and associated risk factors among elderly in a rural block of Tamil Nadu. Indian J Public Health 2018;62:89-94.
3. Balestrieri ML, De Prisco R, Nicolaus B, Pari P, Moriello VS, Strazzullo G, et al. Lycopene in association with alpha-tocopherol or tomato lipophilic extracts enhances acyl-platelet-activating factor biosynthesis in endothelial cells during oxidative stress. Free Radic Biol Med 2004;36:1058–67.
4. Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev 2010;4:118–26.
5. Willner P, Muscat R, Papp M. Chronic mild stress-induced anhedonia: A realistic animal model of depression. Neurosci Biobehav Rev 1992b;16:525-34.