study to assess Vitamin D deficiency and its association with sepsis in tertiary care centre

Abstract

Introduction : Sepsis is a life threatening organ dysfunction generated due to the dysregulation of the immune response to infection. A high mortality rate in sepsis is the result of multiple organ failure which often follows sepsis. Recent studies have shown the correlation between vitamin D deficiency and severe infections and sepsis Aim and objective : To evaluate the correlation between serum levels of vitamin D and outcome of sepsis patients presenting to ED. Methodology : This cross sectional study was performed in the Saraswathi institute of medical sciences, Hapur from October 2021 to March 2022. For all the eligible patients, blood sample was drawn for measuring serum level of vitamin D and finally the correlation between the level of this vitamin and the studied outcomes was evaluated. Result : The mean vit d level of the study subjects who get cured were 23.09±11.20, whereas those patients who died had vit d level 16.12±10.60, on comparing there is significant association of vit d level with outcome of study subjects, with p value 0.02. On assessing  vit D level with TLC of study subjects, on applying regression analysis we found no correlation between vitd level and TLC value of the study subjects with R square 0.   Conclusion : On the basis of our study we can conclude that There is significant association of serum vit d level with outcome of sepsis in the study subjects. On comparing there is significant association of vit d level with outcome of study subjects, with p value 0.02, CRP increases generally in infections, it was associated with vit D level, however association was statistically non-significant.