Abstract
Objective: Nanoemulsions consist of fine oil-in-water dispersions, with droplets covering the size range of 50–500 nm. Olive oil is frequently utilized in cosmetic and pharmaceutical topical product for its healing, protecting, and moisturizing properties due to its high fatty acid and antioxidant content. In the present work, a nanoemulsion composed of olive oil, Span 80 as surfactant, and Labrasol as cosurfactant was developed using a high-pressure homogenization method and was evaluated for its physicochemical characteristics.
Methods: Response surface methodology was utilized to investigate the influence of the main nanoemulsion components: olive oil (X1), Span 80 (X2), and Labrasol (X3) on the droplet size (Y1) and polydispersity index (PDI) (Y2). A total of 17 formulations were generated by the Box-Behnken model.
Results: The model was found to be highly significant with R2 values of 0.9833 and 0.9382 for droplet size and PDI, respectively. The optimized nanoemulsion presented the droplet size of 144.2±0.8 nm and PDI of 0.105±0.014. Span 80 seems to be the most influential factor that determines the droplet size as it has higher significant linear and interaction effects. The developed nanoemulsion was, further, evaluated with an in vivo skin irritancy study using the rat model.
Conclusion: Results indicate that the developed nanoemulsion did not demonstrate any skin irritations in gross and histological examinations, suggesting that it is safe for topical applications.
Publisher
Innovare Academic Sciences Pvt Ltd
Subject
Pharmacology (medical),Pharmaceutical Science,Pharmacology
Reference36 articles.
1. Tavakoli S, Klar AS. Advanced hydrogels as wound dressings. Biomolecules 2020;10:1169. doi: 10.3390/biom10081169, PMID 32796593
2. Silna EA, Krishnakumar K, Nair SK, Narayanan AV. Hydrogels in topical drug delivery-a review. Int J Innov Drug Discov 2016;6:87-93.
3. Bouchemal K, Briançon S, Perrier E, Fessi H. Nano-emulsion formulation using spontaneous emulsification: Solvent, oil and surfactant optimisation. Int J Pharm 2004;280:241-51. doi: 10.1016/j. ijpharm.2004.05.016, PMID 15265563
4. Abolmaali SS, Tamaddon AM, Farvadi FS, Daneshamuz S, Moghimi H. Pharmaceutical nanoemulsions and their potential topical and transdermal applications. Iran J Pharm Sci 2011;7:12.
5. Al-Edresi S, Baie S. In-vitro and in-vivo evaluation of a photo-protective kojic dipalmitate loaded into nano-creams. Asian J Pharm Sci 2010;16:251-65.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献