Abstract
Objectives: The objective of this study was to study the various electrocardiogram (ECG) manifestations in patients who develop acute liver cell failure due to rat killer paste poisoning.
Methods: Patients who developed acute liver cell failure due to rat killer paste ingestion admitted during the time period of July 2022–December 2022 in our institution were taken up for the study. Serial ECG monitoring was done in all these patients and observed for any changes.
Results: Eighty-eight cases of rat killer paste poisoning that developed acute liver failure during this time period were included in the study. Out of 88 patients, 24 patients (27%) had ECG manifestations. The different ECG manifestations are ST depression with T wave inversion – 13 patients (10 expired), QT prolongation – 8 patients (3 expired), sinus bradycardia – 2 patients, and atrial fibrillation with rapid ventricular rate – 1 patient (expired). The mean time of onset of ECG findings is 22 h from intake of poison. The overall mortality rate is 23% (20 patients). About 70% of expired patients (14 patients) had abnormal ECG manifestations.
Conclusion: ST depression with T wave inversion was the most common ECG manifestation due to rat killer paste poisoning in our study and it correlates with mortality. Since cardiotoxicity due to rat killer paste poisoning is also a major contributor to mortality, proper measures have to be taken to create awareness to the general public regarding the toxicity of rat killer paste.
Publisher
Innovare Academic Sciences Pvt Ltd
Reference12 articles.
1. Saoji AA, Lavekar AS, Salkar HR, Pawde GB, Tripathi SS. A case on suicidal poisoning associated with ratol and a perspective on yellow phosphorus poisoning. Int J Recent Trends Sci Technol. 2014;10(2):223-5.
2. Nalabothu M, Monigari N, Acharya R. Clinical profile and outcomes of rodenticide poisoning in tertiary care hospital. Int J Sci Res Publ. 2015;5(8):1-12.
3. El Naggar AR, El Mahdy NM. Zinc phosphide toxicity with a trial of tranexamic acid in its management. J Adv Res. 2011;2(2):149-56. doi: 10.1016/j.jare.2011.01.001
4. Mishra AK, Devakiruba NS, Jasmine S, Sathyendra S, Zachariah A, Iyadurai R. Clinical spectrum of yellow phosphorous poisoning in a tertiary care centre in South India: A case series. Trop Doct. 2017;47(3):245-9. doi: 10.1177/0049475516668986, PMID 27663491
5. Soni JP, Ghormade PS, Akhade S, Chavali K, Sarma B. A fatal case of multi-organ failure in acute yellow phosphorus poisoning. Autopsy Case Rep. 2020;10(1):e2020146. doi: 10.4322/acr.2020.146, PMID 32039071