CURRENT TRENDS OF CUTANEOUS ADVERSE DRUG REACTIONS IN A TERTIARY CARE HOSPITAL IN NORTH INDIA: A RETROSPECTIVE STUDY

Abstract

Objectives: The objectives of this study were as follows: (1) To analyze the reported cutaneous ADRs in a tertiary care hospital for their pattern and suspected medications. (2) To assess the causality and severity of the CADR. Methods: A retrospective study of cutaneous adverse drug reactions (CADRs) reported from July 2020 to August 2023 was conducted. The modified Hartwig and Siegel scale was utilized to evaluate the severity of the reactions, and Naranjo’s causality evaluation scale was employed to determine causality. Results: A total of 187 cases were reported. Maximum cases (48.12%) were between 21 and 40 years age group. The most prevalent CADR pattern was maculopapular rash (57.21%) followed by fixed drug eruption (24.06%). The most common offending drug was diclofenac (9.90%) followed by paracetamol (7.2%). Overall, antimicrobial medicines accounted for the greatest number of CADRs (24.59%). Conclusion: There was a broad range of clinical manifestations of CADRs, from maculopapular rash to severe Steven–Johnson syndrome. Overzealous use of the drugs should be avoided, and proper ADR monitoring should be done for patient safety.