Methodical Approaches to the Study of Human Chromosomal Q-Heterochromatin Variability

Abstract

<p class="1Body">In spite of the fact that chromosomal Q-heterochromatin regions (Q-HRs) in the genome have been opened almost half a century ago, we still know extremely few of their possible roles in the human life activity. One of the reasons of such state is the lack of methodical approaches mostly suitable to the nature and features for chromosomal Q-HRs. In the present work the existing methodical approaches of the human chromosomal Q-HRs has been analyzed, beginning from empirical observations up to the analytical approaches, aimed to detect regularities of Q-HRs distribution and possible effects at population level, in norm and pathology. It is appeared, that all depends on how we consider the nature of chromosomal Q-HRs, namely, whether they are structurally uniform formations in genome or their possible effects depend on features of Q-HRs localization on this or that chromosome in the human karyotype.</p>