Author:
Cannon Kevin,Gandla Deepa,Lauro Samantha,Silverberg Lee,Tierney John,Lagalante Anthony
Abstract
1,3-thiazolidin-4-ones, also known as thiazolidin-4-ones, are known to have a very wide range of biological activity. The corresponding S-oxides may show enhanced activity, and therefore viable synthetic routes to these S-oxides are required. S-oxidation of 3-cyclohexyl-2-phenyl-1,3-thiazolidin-4-ones with Oxone® was investigated. For all compounds evaluated, selective oxidation to the sulfoxide was realized using 3 equivalents of Oxone® at room temperature. Alternatively, the sulfone was prepared selectively at high temperature by increasing the equivalents of Oxone® used; the extent of this selectivity was affected by the substituent of the aromatic ring. In those cases in which the reaction produced a mixture of the sulfoxide and sulfone, the ratio of the products was quantified by 1H NMR.
Publisher
Canadian Center of Science and Education
Cited by
4 articles.
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1. Crystal structures of rac-2,3-diphenyl-2,3,5,6-tetrahydro-4H-1,3-thiazine-1,1,4-trione and N-[(2S,5R)-1,1,4-trioxo-2,3-diphenyl-1,3-thiazinan-5-yl]acetamide;Acta Crystallographica Section E Crystallographic Communications;2023-01-31
2. Applications of Oxone® in Organic Synthesis: An Emerging Green Reagent of Modern Era;ChemistrySelect;2022-06-17
3. Crystal structures of two 1,3-thiazolidin-4-one derivatives featuring sulfide and sulfone functional groups;Acta Crystallographica Section E Crystallographic Communications;2018-11-06
4. Crystal structure of (1S,2S,5R)-5-acetylamino-4-oxo-2,3-diphenyl-1,3-thiazinan-1-ium-1-olate;Acta Crystallographica Section E Crystallographic Communications;2017-09-05