STUDIES ON EXPERIMENTAL PNEUMONIA

Author:

Blake Francis G.1,Cecil Russell L.1

Affiliation:

1. From the Bacteriological Laboratories of the Army Medical School, Washington.

Abstract

1. Lobar pneumonia has been consistently produced in normal monkeys by the intratracheal injection of minute amounts of pneumococcus culture. 2. The disease produced has been shown to be clinically identical with lobar pneumonia in man. 3. Lobar pneumonia has been produced in the monkey in one instance by experimental contact infection. 4. Normal monkeys inoculated in the nose and throat with large amounts of pneumococcus culture have failed to develop lobar pneumonia though carrying the organism in their mouths for at least a month. They have likewise failed to show any evidence of upper respiratory tract infection. 5. Monkeys inoculated subcutaneously or intravenously with pneumococcus culture have in no instance developed pneumonia, but have either died of pneumococcus septicemia or recovered without localization of the infection in the lungs.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

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1. Enzyme Problems in Relation to Chemotherapy, “Adaptation,” Mutations, Resistance, and Immunity;Advances in Enzymology - and Related Areas of Molecular Biology;2006-11-22

2. Spontaneous staphylococcal peritonitis in an otherwise healthy young man;British Journal of Surgery;1993-12

3. Queries and Minor Notes: Then and Now;JAMA;1984-01-20

4. THE RHESUS MONKEY;Veterinary Radiology;1982-11

5. Lung Bacterial Clearance in Murine Pneumococcal Pneumonia;Infection and Immunity;1977-07

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