KINETIC STUDIES ON IMMUNE HEMOLYSIS

Author:

Bowman Walter M.1,Mayer Manfred M.1,Rapp Herbert J.1

Affiliation:

1. From the Department of Bacteriology, School of Hygiene and Public Health of The Johns Hopkins University, Baltimore

Abstract

The reversibility of the red cell-antibody combination has been demonstrated by means of experiments showing the transfer of antibody, either from red cell stromata to intact red cells, or from red cell to red cell. The extent of reversibility is variable with respect to different antisera. The transfer of antibody from stromata to intact red cells is not dependent upon the action of complement. Transfer of antibody can also take place after interaction of the stromata-antibody complex with complement. As a result, antibody molecules can perform hemolytic work over and over again, provided complement is available, and this leads to kinetic behavior of a catalytic character.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Cited by 29 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. THE PRIMARY EQUILIBRIUM BETWEEN ANTIGEN AND ANTIBODY;Annals of the New York Academy of Sciences;2006-12-15

2. Properties of a cell-bound homogeneous murine IgM anti-dextran-V;Immunochemistry;1978-11

3. IMMUNOGLOBULINS;Basic Immunology;1970

4. THE SUBUNITS IN RABBIT ANTI-FORSSMAN IGM ANTIBODY;Journal of Experimental Medicine;1968-05-01

5. Comparative Studies on Rabbit γG and γM Haemolytic Antibodies;International Archives of Allergy and Immunology;1968

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