Affiliation:
1. From the Department of Medicine, Western Reserve University School of Medicine, and University Hospitals, Cleveland
Abstract
Preparations of plasminogen, soluble in aqueous media, increased vascular permeability in guinea pig skin when activated by streptokinase or urokinase. The permeability-enhancing effect was inhibited by soybean trypsin inhibitor but not by triprolidine. Permeability-enhancing activity evolved when plasmin was incubated with fractions of plasma rich in prokinin. The experiments described suggest that plasmin exerts its permeability-increasing effect through the elaboration of kinins.
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Cited by
36 articles.
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