Disruption of the Bcl6 Gene Results in an Impaired Germinal Center Formation-Reference-Cited by-同舟云学术

Disruption of the Bcl6 Gene Results in an Impaired Germinal Center Formation

Published:1997-08-04 Issue:3 Volume:186 Page:439-448
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Fukuda Tetsuya¹¹,Yoshida Takehiko¹,Okada Seiji¹,Hatano Masahiko¹,Miki Tohru¹,Ishibashi Kazuki¹,Okabe Shinichiro¹,Koseki Haruhiko¹,Hirosawa Shinsaku¹,Taniguchi Masaru¹,Miyasaka Nobuyuki¹,Tokuhisa Takeshi¹

Affiliation:

1. From the Division of Developmental Genetics, Center for Biomedical Science, Chiba University School of Medicine, Chiba 260, Japan; the First Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo 113, Japan; and the Core Research for Evolutional Science and Technology, Division of Molecular Immunology, Center for Biomedical Science, Chiba University School of Medicine, Chiba

Abstract

The Bcl6 gene has been identified from the chromosomal translocation breakpoint in B cell lymphomas, and its products are expressed highly in germinal center (GC) B cells. To investigate the function of Bcl6 in lymphocytes, we have generated RAG1-deficient mice reconstituted with bone marrow cells from Bcl6-deficient mice (Bcl6−/−RM). Lymphogenesis in primary lymphoid tissues of Bcl6−/−RM is normal, and Bcl6−/−RM produced control levels of primary IgG1 antibodies specific to T cell–dependent antigens. However, GCs were not found in these mice. This defect was mainly due to the abnormalities of B cells. Therefore, Bcl6 is essential for the differentiation of GC B cells.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/186/3/439/1112853/97-0698.pdf

Reference60 articles.

1. LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas;Kerchaert;Nature Genet,1993

2. Alterations of a zinc finger–encoding gene, BCL-6, in diffuse large-cell lymphoma;Ye;Science (Wash DC),1993

3. Gene involved in the 3q27 translocation associated with B-cell lymphoma, BCL5, encodes a Krüppel-like zinc-finger protein;Miki;Blood,1994

4. LAZ3rearrangements in non-Hodgkin's lymphoma: correlation with histology, immunophenotype, karyotype, and clinical outcome;Bastard;Blood,1994

5. Rearrangements of the BCL6gene in diffuse large cell non-Hodgkin's lymphoma;Lo Coco, F., B.H. Ye, F. Lista., P. Corradini, K. Offit, R. Knoeles, R.S.K. Chaganti, and R. Dalla-Favera;Blood,1994

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