Helper T cell differentiation enters a new era: Le Roi est mort; vive le Roi!-Reference-Cited by-同舟云学术

Helper T cell differentiation enters a new era: Le Roi est mort; vive le Roi!

Published:2006-04-10 Issue:4 Volume:203 Page:809-812
ISSN:1540-9538
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Tato Cristina M.¹,Laurence Arian¹,O'Shea John J.¹

Affiliation:

1. C.M.T., A.L., and J.J.O. are at Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892.

Abstract

In the dark ages of T cell biology, we considered two fates for differentiated CD4+ T cells: T helper (Th)1 and Th2 cells. Now we know that the reality is much more complex and interesting. The newest Th cell subset produces the cytokine IL-17. New evidence shows that the IL-17–related cytokine IL-25 is essential for Th2 responses in two infectious disease models.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/203/4/809/1156674/809.pdf

Reference28 articles.

1. Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium

2. Induction of Experimental Autoimmune Encephalomyelitis in IL-12 Receptor-β2-Deficient Mice: IL-12 Responsiveness Is Not Required in the Pathogenesis of Inflammatory Demyelination in the Central Nervous System

3. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

4. Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract

5. Identification of an interleukin (IL)-25–dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion

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