Landscape of mast cell populations across organs in mice and humans-Reference-Cited by-同舟云学术

Landscape of mast cell populations across organs in mice and humans

Published:2023-07-18 Issue:10 Volume:220 Page:
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Tauber Marie¹²^ORCID,Basso Lilian¹²^ORCID,Martin Jeremy¹²^ORCID,Bostan Luciana¹²^ORCID,Pinto Marlene Magalhaes³^ORCID,Thierry Guilhem R.⁴⁵,Houmadi Raïssa¹²^ORCID,Serhan Nadine¹²^ORCID,Loste Alexia¹²^ORCID,Blériot Camille⁶^ORCID,Kamphuis Jasper B.J.¹²^ORCID,Grujic Mirjana⁷^ORCID,Kjellén Lena⁷^ORCID,Pejler Gunnar⁷^ORCID,Paul Carle¹²⁸^ORCID,Dong Xinzhong⁹¹⁰^ORCID,Galli Stephen J.¹¹¹²^ORCID,Reber Laurent L.¹²^ORCID,Ginhoux Florent¹³¹⁴¹⁵¹⁶¹⁷¹⁸¹⁹^ORCID,Bajenoff Marc⁴⁵^ORCID,Gentek Rebecca³^ORCID,Gaudenzio Nicolas¹²²⁰^ORCID

Affiliation:

1. Toulouse Institute for Infectious and Inflammatory Diseases (Infinity) INSERM 1 , Toulouse, France

2. UMR1291—CNRS UMR5051—University Toulouse III 1 , Toulouse, France

3. Centre for Inflammation Research and Centre for Reproductive Health, Queens Medical Research Institute, University of Edinburgh 2 , Edinburgh, UK

4. Aix Marseille University, CNRS, INSERM 3 , , Marseille, France

5. Centre d'immunologie de Marseille-Luminy 3 , , Marseille, France

6. Institut Necker des Enfants Malades, CNRS UMR8253 4 , Paris, France

7. Uppsala University 5 Department of Medical Biochemistry and Microbiology, , Uppsala, Sweden

8. Toulouse University and Centre Hospitalier Universitaire 6 , Toulouse, France

9. The Solomon H. Snyder Department of Neuroscience, School of Medicine, Center for Sensory Biology, Johns Hopkins University 7 , Baltimore, MD, USA

10. Johns Hopkins University School of Medicine 8 Howard Hughes Medical Institute, , Baltimore, MD, USA

11. Stanford University 9 Departments of Pathology and Microbiology and Immunology, , Stanford, CA, USA

12. Stanford University 10 Sean N. Parker Center for Allergy and Asthma Research, , Stanford, CA, USA

13. Singapore Immunology Network 11 , Singapore, Singapore

14. , Agency for Science, Technology and Research 11 , Singapore, Singapore

15. Gustave Roussy Cancer Campus 12 , Villejuif, France

16. INSERM 13 , Villejuif, France

17. U1015, Gustave Roussy 13 , Villejuif, France

18. Shanghai Institute of Immunology, Shanghai JiaoTong University School of Medicine 14 , Shanghai, China

19. Translational Immunology Institute, SingHealth Duke-NUS Academic Medical Centre 15 , Singapore, Singapore

20. Genoskin SAS 16 , Toulouse, France

Abstract

Mast cells (MCs) are tissue-resident immune cells that exhibit homeostatic and neuron-associated functions. Here, we combined whole-tissue imaging and single-cell RNA sequencing datasets to generate a pan-organ analysis of MCs in mice and humans at steady state. In mice, we identify two mutually exclusive MC populations, MrgprB2+ connective tissue–type MCs and MrgprB2neg mucosal-type MCs, with specific transcriptomic core signatures. While MrgprB2+ MCs develop in utero independently of the bone marrow, MrgprB2neg MCs develop after birth and are renewed by bone marrow progenitors. In humans, we unbiasedly identify seven MC subsets (MC1–7) distributed across 12 organs with different transcriptomic core signatures. MC1 are preferentially enriched in the bladder, MC2 in the lungs, and MC4, MC6, and MC7 in the skin. Conversely, MC3 and MC5 are shared by most organs but not skin. This comprehensive analysis offers valuable insights into the natural diversity of MC subtypes in both mice and humans.

Funder

National Institutes of Health

National Institute of Allergy and Infectious Diseases

Agence Nationale de la Recherche

H2020 European Research Council

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

https://rupress.org/jem/article-pdf/doi/10.1084/jem.20230570/1455093/jem_20230570.pdf

Reference75 articles.