Competitive fungal commensalism mitigates candidiasis pathology-Reference-Cited by-同舟云学术

Competitive fungal commensalism mitigates candidiasis pathology

Published:2024-03-18 Issue:5 Volume:221 Page:
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Sekeresova Kralova Jarmila¹^ORCID,Donic Catalina¹^ORCID,Dassa Bareket²^ORCID,Livyatan Ilana³^ORCID,Jansen Paul Mathias⁴^ORCID,Ben-Dor Shifra²^ORCID,Fidel Lena²^ORCID,Trzebanski Sébastien¹^ORCID,Narunsky-Haziza Lian³^ORCID,Asraf Omer⁵^ORCID,Brenner Ori⁶^ORCID,Dafni Hagit⁶^ORCID,Jona Ghil²^ORCID,Boura-Halfon Sigalit¹^ORCID,Stettner Noa⁶^ORCID,Segal Eran³^ORCID,Brunke Sascha⁴^ORCID,Pilpel Yitzhak⁵^ORCID,Straussman Ravid³^ORCID,Zeevi David⁷^ORCID,Bacher Petra⁸⁹^ORCID,Hube Bernhard⁴¹⁰^ORCID,Shlezinger Neta¹¹^ORCID,Jung Steffen¹^ORCID

Affiliation:

1. Weizmann Institute of Science 1 Departments of Immunology and Regenerative Biology, , Rehovot, Israel

2. Life Sciences Core Facilities, Weizmann Institute of Science 2 , Rehovot, Israel

3. Molecular Cell Biology, Weizmann Institute of Science 3 , Rehovot, Israel

4. Leibniz Institute for Natural Product Research and Infection Biology—Hans Knoell Institute Jena (HKI) 4 Department of Microbial Pathogenicity Mechanisms, , Jena, Germany

5. Molecular Genetics, Weizmann Institute of Science 5 , Rehovot, Israel

6. Veterinary Resources, Weizmann Institute of Science 6 , Rehovot, Israel

7. Plant and Environmental Sciences, Weizmann Institute of Science 7 , Rehovot, Israel

8. Institute of Immunology, Christian-Albrecht-University of Kiel 8 , Kiel, Germany

9. Institute of Clinical Molecular Biology, Christian-Albrecht-University of Kiel 9 , Kiel, Germany

10. Institute of Microbiology, Friedrich Schiller University 10 , Jena, Germany

11. The Robert H. Smith Faculty of Agriculture, Food and Environment The Hebrew University of Jerusalem 11 , Rehovot, Israel

Abstract

The mycobiota are a critical part of the gut microbiome, but host–fungal interactions and specific functional contributions of commensal fungi to host fitness remain incompletely understood. Here, we report the identification of a new fungal commensal, Kazachstania heterogenica var. weizmannii, isolated from murine intestines. K. weizmannii exposure prevented Candida albicans colonization and significantly reduced the commensal C. albicans burden in colonized animals. Following immunosuppression of C. albicans colonized mice, competitive fungal commensalism thereby mitigated fatal candidiasis. Metagenome analysis revealed K. heterogenica or K. weizmannii presence among human commensals. Our results reveal competitive fungal commensalism within the intestinal microbiota, independent of bacteria and immune responses, that could bear potential therapeutic value for the management of C. albicans–mediated diseases.

Funder

Israeli Science Foundation

Weizmann Institute

Morris Kahn Institute for Human Immunology

Henry H. Drake Professorial Chair of Immunology

Deutsche Forschungsgemeinschaft

Publisher

Rockefeller University Press

Link

https://rupress.org/jem/article-pdf/doi/10.1084/jem.20231686/1926513/jem_20231686.pdf

Reference78 articles.

1. Candida albicans-induced epithelial damage mediates translocation through intestinal barriers;Allert;MBio,2018