Affiliation:
1. From the Department of Health, Education, and Welfare, Public Health Service, The Metabolism Service and Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda
Abstract
Two subclasses of mouse 7S γ2-globulins are identified, and are designated γ2a- and γ2b-globulins. They are distinguished from 7S γ1-globulins, γ1A (ß2A)-globulins, and γ1M-globulins of mouse serum. Antibody activity was detected among the γ2a-globulins and γ2b-globulins of hyperimmune mouse serum.
γ2a- and γ2b-myeloma proteins were identified. The genetically determined isoantigen, Iga-1, was present on γ2a-myeloma proteins, but not on γ2b-myeloma proteins.
These findings indicate a complexity among the 7S γ2-globulins which must be taken into account in structural, functional, and genetic studies of immunoglobulins.
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Cited by
94 articles.
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