EPIDEMIC DIARRHEAL DISEASE OF SUCKLING MICE

Author:

Cheever F. Sargent1,Mueller J. Howard1

Affiliation:

1. From the Department of Bacteriology and Immunology, Harvard Medical School, Boston

Abstract

Four strains of mice—Harvard, Schwentker, CFW (Carworth Farms), and C (National Cancer Institute)—have been kept and bred underidentical conditions over the course of a year in order to determine the effect of strain, of litter, and of season upon the incidence of diarrheal disease among the suckling mice. 1. Significant strain differences were limited to CFW mice. A consistently lower percentage of these mice were weaned in comparison to the others. 2. The effect of litter was definite and consistent: In all four strains first litters fared worse than second and third ones, while fourth and fifth litters showed the highest percentage of mice weaned. 3. The effect of season seemed clear cut only in the case of one strain CFW; the highest percentage of mice weaned were observed during the summer months and the lowest during the autumn and early winter.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Cited by 22 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

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2. The Immunology of Rotavirus Infection in the Mouse;Advances in Virus Research;1998

3. Murine experimental infection with rotavirus SA-11: clinical and immunohistological characteristics;Experimental and Toxicologic Pathology;1994-01

4. Development of an adult mouse model for studies on protection against rotavirus;Journal of Virology;1990-10

5. Viral Gastroenteritis in Ruminants;Virus Infections of Ruminants;1990

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