DNA rearrangement and constitutive expression of the interleukin 6 gene in a mouse plasmacytoma.-Reference-Cited by-同舟云学术

DNA rearrangement and constitutive expression of the interleukin 6 gene in a mouse plasmacytoma.

Published:1990-03-01 Issue:3 Volume:171 Page:965-970
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Blankenstein T¹,Qin Z H¹,Li W Q¹,Diamantstein T¹

Affiliation:

1. Institut für Immunologie, Klinikum Steglitz, Freie Universität Berlin, Federal Republic of Germany.

Abstract

To study the potential involvement of IL-6 in the development of plasmacytomas, a number of plasmacytoma lines were analyzed for alterations in the IL-6 locus. A DNA rearrangement due to the insertion of an intracisternal A particle retrotransposon 18 bp 5' of the transcriptional start site was detected in the cell line MPC11. The IL-6 gene is constitutively expressed in MPC11, suggesting the involvement of IL-6 in the development of certain myeloma/plasmacytomas according to the "autocrine growth hypothesis".

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/171/3/965/1100117/965.pdf

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