OBSERVATIONS ON THE RELEASE OF SERUM FIBRINOLYSIN BY SPECIFIC ANTIGEN, PEPTONE, AND CERTAIN POLYSACCHARIDES

Author:

Ungar Georges1,Mist Shirley H.1

Affiliation:

1. From the Rheumatic Fever Research Institute, Northwestern University Medical School, Chicago

Abstract

Formation of fibrinolysin from its inactive precursor in serum was observed under the following conditions: (a) by adding the specific antigen to serum from sensitized guinea pigs; (b) by mixing normal guinea pig serum with peptone, agar, hyaluronic acid, chondroitinsulfuric acid, glycogen, pneumococcal polysaccharides, and heparin. Activation of profibrinolysin by these agents differs from chloroform or streptokinase activation in that it requires the presence of some serum constituent non-precipitable with the euglobulin fraction and destroyed by heating at 56°C. The bearing of these observations on the mechanism of anaphylactic and anaphylactoid reactions is discussed. The findings reported support the concept that proteolysis is part of the process determining the release of histamine and other toxic products. It is suggested that the presence of fibrinokinase may be responsible for the toxicity of serum induced in vitro by a number of agents.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Cited by 112 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Effect of Acid Polysaccharides on the Fibrinolytic System in Guinea-Pig Serum.;Acta Pharmacologica et Toxicologica;2009-05-19

2. Variations in Non-Specific Activation of Fibrinolytic System in Sera of Different Species;Acta Pharmacologica et Toxicologica;2009-03-13

3. Peptone Activation of a Serum Fibrinolytic System.;Acta Pharmacologica et Toxicologica;2009-03-13

4. The Pharmacological Effects of Polysaccharides;Ciba Foundation Symposium - Chemistry and Biology of Mucopolysaccharides;2008-05-30

5. POSSIBLE SIGNIFICANCE OF BRADYKININ IN THE SHWARTZMAN AND OTHER PHENOMENA*;Annals of the New York Academy of Sciences;2006-12-15

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3