ACTIVATION OF PROFIBRINOLYSIN BY ANTIGEN-ANTIBODY REACTION AND BY ANAPHYLACTOID AGENTS; ITS RELATION TO COMPLEMENT

Author:

Ungar Georges1,Damgaard Evelyn1,Hummel Fred P.1

Affiliation:

1. From the Rheumatic Fever Research Institute, Northwestern University Medical School, Chicago

Abstract

The activation of profibrinolysin in sensitized guinea pig serum when mixed in vitro with the homologous antigen was confirmed with a more accurate and more reliable method than the one previously used. A study was made of some of the conditions required for obtaining maximum activation. Profibrinolysin activation was also induced in normal guinea pig serum by addition of certain "anaphylactoid" agents such as peptone, tween 20, morphine, octylamine, octadecylamine, and 48/80. The specific antigen and the anaphylactoid agents produce activation only when added to whole, fresh, unheated serum. Profibrinolysin activation by these agents, as opposed to activation by streptokinase, seems to require the intervention of a kinase system (serofibrinokinase) inactivated by fractionation of serum and by heating to 56°C. Whenever serum was submitted to treatments which caused fractionation, fixation or inhibition of complement, serofibrinokinase was also inactivated. Under the conditions investigated the behavior of this kinase was indistinguishable from that of complement.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Cited by 55 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Effect of Acid Polysaccharides on the Fibrinolytic System in Guinea-Pig Serum.;Acta Pharmacologica et Toxicologica;2009-05-19

2. Effect of Anionic Polyelectrolytes on the Fibrinolytic System of Guinea Pig Serum;Acta Pharmacologica et Toxicologica;2009-03-13

3. Variations in Non-Specific Activation of Fibrinolytic System in Sera of Different Species;Acta Pharmacologica et Toxicologica;2009-03-13

4. Peptone Activation of a Serum Fibrinolytic System.;Acta Pharmacologica et Toxicologica;2009-03-13

5. Detection of Plasminogen Activator in Macrophage Culture Supernatants by a Photometric Assay;Hoppe-Seyler´s Zeitschrift für physiologische Chemie;1980-01

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