CULTURAL STUDIES ON MOUTH SPIROCHÆTÆ (TREPONEMA MICRODENTIUM AND MACRODENTIUM)

Author:

Noguchi Hideyo1

Affiliation:

1. From the Laboratories of The Rockefeller Institute for Medical Research, New York.

Abstract

I have described the successful cultivation of two distinct species of Treponema from the oral cavity of man. The species differ from one another morphologically and in respect to their cultural properties. As the two species have now been clearly separated and cultivated for the first time, I propose for them the names Treponema microdentium and macrodentium, respectively. Division along the longitudinal axis has been demonstrated for both Treponema macrodentium and microdentium. When the micro- and macrodentium are cultivated under imperfect anaerobic conditions, they undergo involution, but still continue to vegetate to some extent. Finally, a spiral organism has been cultivated and described that may be merely an involuted form of the macrodentium, or it may be a new species altogether.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

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1. A review of in vitro attempts to develop the axenic culture of Treponema pallidum and genomics-based suggestions to achieve this elusive goal;Journal of Medical Microbiology;2021-07-30

2. Treponema phagedenis (ex Noguchi 1912) Brumpt 1922 sp. nov., nom. rev., isolated from bovine digital dermatitis;International Journal of Systematic and Evolutionary Microbiology;2020-03-01

3. Activation of the Innate Immune System by Treponema denticola Periplasmic Flagella through Toll-Like Receptor 2;Infection and Immunity;2018-01

4. Virulence factor of Treponema denticola;Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology);2017

5. Treponema;Bergey's Manual of Systematics of Archaea and Bacteria;2015-09-14

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