ANTIDIURETIC PITUITARY SUBSTANCE IN BLOOD, WITH SPECIAL REFERENCE TO THE TOXEMIA OF PREGNANCY

Author:

Melville K. I.1

Affiliation:

1. From the Department of Pharmacology, McGill University, Montreal

Abstract

A method is described for the quantitative extraction of posterior pituitary antidiuretic substance from blood with which it has been mixed in vitro and in vivo for experimental purposes. With this procedure, it is found that a similarly extractable active substance may be detected as a normal constituent of dog and human blood. The data obtained from the blood of normal pregnancies and several cases of early toxemia, do not indicate any causal relationship between the presence of this substance in the circulating blood and the early symptoms (hypertension, edema, albuminuria) of the toxemia of pregnancy.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Cited by 42 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. The Assay of Neurohypophysial Hormones in Blood and Other Body Fluids;Neurohypophysial Hormones and Similar Polypeptides;1968

2. Oxytocic Factors in the Plasma of the Human Male;Fertility and Sterility;1964-03

3. Adiuretinuntersuchungen w�hrend der normalen Schwangerschaft und bei Gestosen;Archiv f�r Gyn�kologie;1960

4. The plasma antidiuretic activity in toxemia of pregnancy;American Journal of Obstetrics and Gynecology;1958-06

5. Mammalian Antidiuretic Hormone;Physiological Reviews;1958-04-01

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