SEROLOGICAL DISTINCTION OF MUTANTS B6.C-H(z1) AND B6.M505 FROM STRAIN C57BL/6

Author:

Klein Jan1,Hauptfeld Miroslav1,Hauptfeld Věra1

Affiliation:

1. From the Department of Microbiology, The University of Texas Southwestern Medical School, Dallas, Texas 75235

Abstract

A quantitative serological difference was found between strains Hz1 and M505 carrying mutant H-2 haplotypes ba and bd, respectively, and the original strain B6(H-2b). The finding suggests that the mutations occurred in the H-2Kb gene, and together with data on MLR and CML challenges the current concept of H-2 regions' involvement in immune reactions.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

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