Regulation of brain insulin signaling: A new function for tau-Reference-Cited by-同舟云学术

Regulation of brain insulin signaling: A new function for tau

Published:2017-06-26 Issue:8 Volume:214 Page:2171-2173
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Gratuze Maud¹,Planel Emmanuel¹

Affiliation:

1. Faculté de Médecine, Département de Psychiatrie et Neurosciences, Université Laval, Québec, QC, Canada; Centre de Recherche du CHU de Québec, Québec, QC, Canada

Abstract

In this issue of JEM, Marciniak et al. (https://doi.org/10.1084/jem.20161731) identify a putative novel function of tau protein as a regulator of insulin signaling in the brain. They find that tau deletion impairs hippocampal response to insulin through IRS-1 and PTEN dysregulation and suggest that, in Alzheimer’s disease, impairment of brain insulin signaling might occur via tau loss of function.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/214/8/2171/1168967/jem_20170979.pdf

Reference16 articles.

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