Affiliation:
1. Institute of Neuropathology, University of Zurich, Zurich, Switzerland
Abstract
In this issue of JEM, Krejciova et al. (https://doi.org/10.1084/jem.20161547) report that astrocytes derived from human iPSCs can replicate human CJD prions. These observations provide a new, potentially very valuable model for studying human prions in cellula and for identifying antiprion compounds that might serve as clinical candidates. Furthermore, they add to the evidence that astrocytes may not be just innocent bystanders in prion diseases.
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Cited by
23 articles.
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