STAT3 gain of function: Too much of a good thing in the skin!-Reference-Cited by-同舟云学术

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STAT3 gain of function: Too much of a good thing in the skin!

Published:2024-07-01 Issue:8 Volume:221 Page:
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Ma Cindy S.¹²^ORCID,Tangye Stuart G.¹²^ORCID

Affiliation:

1. Garvan Institute of Medical Research 1 , Darlinghurst, Australia

2. School of Clinical Medicine, UNSW Sydney 2 Faculty of Medicine and Health, , Darlinghurst, Australia

Abstract

Germline activating mutations in STAT3 cause a multi-systemic autoimmune and autoinflammatory condition. By studying a mouse model, Toth et al. (https://doi.org/10.1084/jem.20232091) propose a role for dysregulated IL-22 production by Th17 cells in causing some aspects of immune-mediated skin inflammation in human STAT3 GOF syndrome.

Funder

National Health and Medical Research Council of Australia

Publisher

Rockefeller University Press

Link

https://rupress.org/jem/article-pdf/doi/10.1084/jem.20240849/1929947/jem_20240849.pdf

Reference14 articles.

1. Inborn Errors of Human JAKs and STATs

2. Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease

3. Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome

4. The ups and downs of STAT3 function: too much, too little and human immune dysregulation

5. STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+ T cell dysregulation and accumulation

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