Sounding the alarm in the lung with TL1A-Reference-Cited by-同舟云学术

Sounding the alarm in the lung with TL1A

Published:2024-04-10 Issue:6 Volume:221 Page:
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Pires Silvia¹^ORCID,Longman Randy S.¹^ORCID

Affiliation:

1. Jill Roberts Center and Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine 1 Division of Gastroenterology and Hepatology, Department of Medicine, , New York, NY, USA

Abstract

Environmental airborne antigens are central to the development of allergic asthma, but the cellular processes that trigger disease remain incompletely understood. In this report, Schmitt et al. (https://doi.org/10.1084/jem.20231236) identify TNF-like protein 1A (TL1A) as an epithelial alarmin constitutively expressed by a subset of lung epithelial cells, which is released in response to airborne microbial challenge and synergizes with IL-33 to drive allergic disease.

Publisher

Rockefeller University Press

Link

https://rupress.org/jem/article-pdf/doi/10.1084/jem.20240389/1927172/jem_20240389.pdf

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5. ATNFSF15disease-risk polymorphism increases pattern-recognition receptor-induced signaling through caspase-8–induced IL-1