Neutrophil IL-26 fuels autoinflammation-Reference-Cited by-同舟云学术

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Neutrophil IL-26 fuels autoinflammation

Published:2024-04-01 Issue:5 Volume:221 Page:
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Futosi Krisztina¹²^ORCID,Mócsai Attila¹²^ORCID

Affiliation:

1. Semmelweis University School of Medicine 1 Department of Physiology, , Budapest, Hungary

2. HUN-REN–SU Inflammation Physiology Research Group, Hungarian Research Network and Semmelweis University 2 , Budapest, Hungary

Abstract

Pustular psoriasis is an inflammatory skin disease with features of neutrophil-mediated sterile autoinflammation. In this issue of JEM, Baldo et al. (https://doi.org/10.1084/jem.20231464) show that this autoinflammation is driven by a vicious cycle through neutrophil-derived IL-26.

Funder

Hungarian National Research, Development, and Innovation Office

HUN-REN Hungarian Research Network

Publisher

Rockefeller University Press

Link

https://rupress.org/jem/article-pdf/doi/10.1084/jem.20240229/1926704/jem_20240229.pdf

Reference16 articles.

1. Trial of Spesolimab for Generalized Pustular Psoriasis

2. Human neutrophils drive skin autoinflammation by releasing interleukin (IL)-26

3. Differentiation of IL-26+ TH17 intermediates into IL-17A producers via epithelial crosstalk in psoriasis

4. Immunobiology of IL-26

5. Characterization of novel anti-IL-26 neutralizing monoclonal antibodies for the treatment of inflammatory diseases including psoriasis

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