THE SYNTHESIS, ASSEMBLY, AND SECRETION OF GAMMA GLOBULIN BY MOUSE MYELOMA CELLS-Reference-Cited by-同舟云学术

THE SYNTHESIS, ASSEMBLY, AND SECRETION OF GAMMA GLOBULIN BY MOUSE MYELOMA CELLS

Published:1973-07-01 Issue:1 Volume:138 Page:278-288
ISSN:1540-9538
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Buxbaum J.¹,Scharff M. D.¹

Affiliation:

1. From the Department of Medicine, Manhattan Veterans Administration Hospital, New York 10010; the Rheumatic Diseases Study Group and Department of Medicine, New York University School of Medicine, New York 10016; and the Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461

Abstract

The study of the synthesis, assembly, and secretion of IgM by seven murine myeloma tumors has revealed that free mu chain can be detected intracellularly after release from the ribosome. It combines with light chains to form µL. The major intracellular protein in six of the seven tumors was the 8S subunit. One tumor contained considerable amounts of 19S material intracellularly. Those tumors that did not contain 19S IgM intracellulariy appeared to assemble the subunits outside the cell.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/138/1/278/1085583/278.pdf

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