Endogenous superantigen expression is controlled by mouse mammary tumor proviral loci.

Author:

Woodland D L1,Lund F E1,Happ M P1,Blackman M A1,Palmer E1,Corley R B1

Affiliation:

1. Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.

Abstract

Superantigens are defined by their ability to stimulate T cells based predominantly on their V beta expression and ability to delete T cells in the thymus when expressed endogenously. We show here that the expression of one endogenous superantigen, Etc-1, is controlled by the expression of the open reading frame region of the 3' long terminal repeat of the mouse mammary tumor proviral gene, Mtv-9. We show that Mtv-8 controls a superantigen with similar specificity, and that both Mtv-8 and Mtv-9 stimulate some V beta 17+ T cells. A third provirus, Mtv-6, controls a superantigen with specificity for V beta 3. Data presented raise the possibility that endogenous superantigens may compete for class II molecules in a single B cell.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

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