Affiliation:
1. From the House of the Good Samaritan and the Department of Medicine, Children's Hospital Medical Center, and the Department of Pediatrics, Harvard Medical Center, Boston
Abstract
"Natural" antibodies to representative species of Enterobacteriaceae were found to be principally associated with the γ1-macroglobulin prepared from Cohn fraction III-I of pooled human plasma. The amount of antibodies present was estimated by measuring the bactericidal, hemagglutinating, mouse-protective, and opsonophagocytic activities of this fraction. Comparison with the antibody activity of γ2-globulin of Cohn fraction II showed that up to 100 times more antibody activity on a weight basis was present in the macroglobulin fraction. These findings suggest that differences between natural and immune antibody result from the physicochemical properties of 2 different classes of immune globulin.
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Cited by
101 articles.
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