SARS-CoV-2–related MIS-C: A key to the viral and genetic causes of Kawasaki disease?
Author:
Sancho-Shimizu Vanessa12ORCID, Brodin Petter3ORCID, Cobat Aurélie456ORCID, Biggs Catherine M.78ORCID, Toubiana Julie910ORCID, Lucas Carrie L.11ORCID, Henrickson Sarah E.1213ORCID, Belot Alexandre1415ORCID, Haddad Elie, Beland Kathie, Pujol Aurora, Schlüter Agatha, Planas-Serra Laura, Aguilera-Albesa Sergio, Valencia-Ramos Juan, Rodríguez-Palmero Agustí, Gut Marta, Rivière Jacques G., Colobran Roger, Soler-Palacin Pere, Rodriguez-Gallego Carlos, Perez De Diego Rebeca, Flores Carlos, Alsina Laia, Blazquez-Gamero Daniel, Jordan Iolanda, Keles Sevgi, Emiroglu Melike, Akcan Ozge Metin, Alkan Gulsum, Aytekin Selma Erol, Gul Yahya, Tüter Öz Şadiye Kübra, Bozdemir Sefika Elmas, Bayhan Gulsum Iclal, Yüksek Saliha Kanık, Parlakay Aslınur Özkaya, Gülhan Belgin, Yahşi Aysun, Kilic Ahmet Osman, Karbuz Adem, Erdeniz Emine Hafize, Özkan Esra Akyüz, Orbak Zerrin, Aydemir Şehnaz, Celik Jale Bengi, Kandemir Bahar, Aytekin Gökhan, Kapakli Hasan, Yarar Volkan, Yosunkaya Alper, Vatansev Hulya, Aytekin Caner, Torun Selda Hancerli, Nepesov Serdar, Coskuner Taner, Sözeri Betül, Demirkol Yasemin Kendir, Kasapcopur Ozgur, Yıldız Mehmet, Sevketoglu Esra, Hatipoğlu Nevin, Özçelik Tayfun, Yesilbas Osman, Gayretli Aydin Zeynep Gökçe, Sediva Anna, Klocperk Adam, Bloomfield Marketa, Meyts Isabelle, Delafontaine Selket, Haerynck Filomeen, Hoste Levi, Shahrooei Mohammad, Marque Laura, Neves João Farela, Novelli Giuseppe, Novelli Antonio, Aiuti Alessandro, Casari Giorgio, Bousfiha Amed Aziz, Almuhsen Saleh Zaid, Sobh Ali, Gagro Alenka, Bajolle Fanny, Bonnet Damien, Lebon Pierre, Lei Weite, Lee Danyel, Seeleuthner Yoann, Zhang Peng, Maglorius Majistor, Philippot Quentin, Pelham Simon, Bastard Paul, Zhang Qian, Jouanguy Emmanuelle, Puel Anne, Herberg Jethro, Kuijpers Taco W, Bellos Evangelos, Kaforou Myrsini, Menikou Stephanie, Pan-Hammarström Qiang, Hammarström Lennart, Abolhassani Hassan, Bryceson Yenan, Condino-Neto Antonio, Prando Carolina, Bando Silvia Yumi, Cavalcanti Andre, Fellay Jacques, Blanchard-Rohner Geraldine, Mansouri Davood, Mahmoudi Shima, Boyarchuk Oksana, Volokha Alla, Bondarenko Anastasiia, Stepanovskiy Yuriy, Mogensen Trine, van de Beek Diederik, Andreakos Evangelos, Papadaki Maria, Abou Tayoun Ahmad, Halwani Rabih, Al-Mulla Fahd, Franco José Luis, Lau Yu-Lung, Kwan Mike, Imai Kohsuke, Okada Satoshi, Bolze Alexandre, Butte Manish J., Hsieh Elena, Drolet Beth A, Arkin Lisa, Itan Yuval, Maniatis Tom, Arditi Moshe, Cooper Megan, Schmitt Erica, Chakravorty Samya, Anderson Mark S., Su Helen C., Notarangelo Luigi D., Tangye Stuart G.1617ORCID, Milner Joshua D.18ORCID, Levin Michael12ORCID, Abel Laurent456ORCID, Bogunovic Dusan19ORCID, Casanova Jean-Laurent45620ORCID, Zhang Shen-Ying456ORCID,
Affiliation:
1. Department of Paediatric Infectious Diseases and Virology, Imperial College London, London, UK 2. Centre for Paediatrics and Child Health, Faculty of Medicine, Imperial College London, London, UK 3. Science for Life Laboratory, Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden 4. St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 5. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale, Necker Hospital for Sick Children, Paris, France 6. University of Paris, Imagine Institute, Paris, France 7. Department of Pediatrics, University of British Columbia, Vancouver, Canada 8. British Columbia Children’s Hospital Research Institute, Vancouver, Canada 9. Department of General Pediatrics and Pediatric Infectious Diseases, Necker Hospital for Sick Children, Assistance Publique - Hôpitaux de Paris, University of Paris, Paris, France 10. Pasteur Institute, Biodiversity and Epidemiology of Bacterial Pathogens, Paris, France 11. Department of Immunobiology, Yale University School of Medicine, New Haven, CT 12. Division of Allergy Immunology, Children’s Hospital of Philadelphia, Philadelphia, PA 13. Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 14. Centre International de Recherche en Infectiologie, University of Lyon, Institut National de la Santé et de la Recherche Médicale, U1111, Université Claude Bernard, Lyon 1, Le Centre National de la Recherche Scientifique, UMR5308, Lyon, France 15. National Reference Center for Rheumatic, Autoimmune and Systemic Diseases in Children (RAISE), Pediatric Nephrology, Rheumatology, Dermatology Unit, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Lyon, France 16. Garvan Institute of Medical Research, Darlinghurst, Australia 17. St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales Sydney, Sydney, Australia 18. Department of Pediatrics, Columbia University Irving Medical Center, New York, NY 19. Center for Inborn Errors of Immunity, Precision Immunology Institute, Mindich Child Health and Development Institute, Department of Microbiology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 20. Howard Hughes Medical Institute, New York, NY
Abstract
Multisystem inflammatory syndrome in children (MIS-C) emerged in April 2020 in communities with high COVID-19 rates. This new condition is heterogenous but resembles Kawasaki disease (KD), a well-known but poorly understood and clinically heterogenous pediatric inflammatory condition for which weak associations have been found with a myriad of viral illnesses. Epidemiological data clearly indicate that SARS-CoV-2 is the trigger for MIS-C, which typically occurs about 1 mo after infection. These findings support the hypothesis of viral triggers for the various forms of classic KD. We further suggest that rare inborn errors of immunity (IEIs) altering the immune response to SARS-CoV-2 may underlie the pathogenesis of MIS-C in some children. The discovery of monogenic IEIs underlying MIS-C would shed light on its pathogenesis, paving the way for a new genetic approach to classic KD, revisited as a heterogeneous collection of IEIs to viruses.
Funder
Howard Hughes Medical Institute Rockefeller University St. Giles Foundation National Institutes of Health National Center for Advancing Translational Sciences Yale Center for Mendelian Genomics GSP Coordinating Center National Human Genome Research Institute Institut National de la Santé et de la Recherche Médicale Université de Paris UK Research and Innovation Future Leader’s Fellowship NIHR Imperial Biomedical Research Centre Imperial College Healthcare NHS Trust Burroughs Wellcome Fund Clinical Immunology Society American Academy of Allergy Asthma and Immunology Michael Smith Foundation for Health Research National Health and Medical Research Council University of New South Wales French National Research Agency French Foundation for Medical Research Square Foundation Grandir - Fonds de solidarité pour l’enfance Fondation du Souffle SCOR Corporate Foundation for Science
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Cited by
100 articles.
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